EFFECTS OF INTRAVENOUS FAT EMULSION ON O(2) TRANSPORT AND ALVEOLAR-ARTERIAL GAS TENSIONS IN DOGS
Abstract
Ten dogs were made progressively hypoxic by rebreathing from an air-filled spirometer. Arterial blood samples were drawn at five levels of alveolar Po2 (100, 70, 55, 40, and 25 mm. Hg). Additional samples for the determination of O2 capacity were drawn before and after the progressive hypoxia. Half the animals were then given 25 ml./kg. of fat emulsion intravenously and the others were given the same amount of dextran. The same sampling procedure was repeated and the bloods were analyzed for O2 content. In separate experiments, the same procedure was followed for 5 dogs but only Lipomul was iven and the arterial blood was analyzed for Po2 and Pco . Oxyhemoglobin dissociation curves were constructed from the values of saturation at progressively falling alveolar Po2. These were transformed into a linear equation by the Hill equation and treated statistically. No significant differences were found between any of the comparisons made of slope or displacement. It was concluded that lipemia offered no practical hindrance to the uptake of O2 by the red cell. Alveolar-arterial gas tension differences revealed no change after intravenous fat emulsion in the Po2 difference, but there was a threefold increase in the Pco2 difference. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1961
- Accession Number
- AD0267004
Entities
People
- Stephen M Cain
Organizations
- United States Air Force School of Aerospace Medicine