CHOLESTEROL AND FATTY ACID BIOSYNTHESIS IN BRAIN
Abstract
The problem of cholesterol biosynthesis in brain of suckling rats was studied. The effect of experimental conditions known to affect liver cholesterol and brain lipid synthesis was studied. The administration of Triton WR 1339 results in an increase of cholesterol synthesis in liver and, to a lesser degree, in brain when 1- C14 acetate, but not 2- C14 mevalonolactone, is used as precursor. Gamma-irradiation increases the cholesterol synthesis in liver but shows an opposite effect on such a synthesis in brain. After partial hepatectomy there is an increase of cholesterol synthesis in regenerating liver, using acetate as precursor, but no change occurs in brain. Exposure to low oxygen tension considerably decreases cholesterol synthesis in liver but shows no effect on brain. Thyroxine analogues, biphenylacetic acid derivatives, nicotinic acid, benzmalacene, MER-29, heparinoid and hexoestrol at various dose levels, do not affect the concentration of brain cholesterol.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 1961
- Accession Number
- AD0267228
Entities
People
- E. Grossi
- K. Gopal
- L. Bizzi
- M. Poggi
- P. Paoletti
- S. Garattini
Organizations
- University of Milan