ON THE MECHANISM OF INHIBITION OF T2 BACTERIOPHAGE BY MUSTARD GAS

Abstract

The object of this study was to investigate the mechanism by which mustard gas inhibits cellular reproduction, with the eventual goal of establishing a rationale for reversal of the lethal damages. The T2 bacteriophage system was used as a model for investigating the action of the agent on biochemical and genetic aspects of reproduction. The effect of mustard gas on the in vitro synthesis of deoxyribonucleic acid was also studied. The findings were discussed at length with respect to the site of action of mustard gas, some genetic and metabolic consequences to the virus, and some possible approaches to therapy. (Author)

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1961
Accession Number
AD0267365

Entities

People

  • Bruno Papirmeister

Organizations

  • Edgewood Chemical Biological Center

Tags

DTIC Thesaurus Topics

  • Acids
  • Bacteriophages
  • Chemical Warfare Agents
  • Chemical Weapons
  • Deoxyribonucleic Acids
  • Inhibition
  • Mustard Agents
  • Viruses

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biology
  • Plasma Physics.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology