KIDNEY FUNCTION: DIODRAST-I(131) CONCENTRATION WITHIN TUBULAR CELLS; EFFECTS OF INHIBITORS, COLD AND DIURESIS
Abstract
URING THE FIRT PHASE, THE PROJECT' INIIAL AIMS WERE FULLY ACHIEVED IN THE FORM OF A COMBINED AORADIOGRAPHIC AND RENAL CLEARANCE STUDY OF Diodast-I(131) transport in Necturus kdney. The quntitative auoradiographic approach was mos productive of new inforation concerning tublar tansport of this compound. In addiion, the choice of Necturu a experimentl animal wa partiularly rewading since this species was disovered to exhibit a hitherto unknown feaure, simltaneous bidirectonal transport of Diodast-lie compounds acoss proximal tubular cells. The study on Necurus kidney is reviewed. The second and final phase consisted of a sdy of Diodrast-I(31) run-ou from goldfish kiney in vitro. This study was designed to extend the observations first made in Necturus and proved to be equally productive of new informaton. The concept of exchange diffusion, recently developed by workers in other transport fields, was for the first tme implicated in tubuar cell transport of Diodrast and relted compounds. This finding opens a whole new approach to understanding the fundamental mechanisms underlying such trnsport. The stuy on goldfish kidney is reviewed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 31, 1961
- Accession Number
- AD0267797
Entities
People
- Eugene M. Landis
- William B. Kinter
Organizations
- Harvard Medical School