In Vivo Specific Activity Studies of Iron-Containing Fractions of Normal Rat Blood,
Abstract
Determinations of stable iron and radioion were made on cells, intact serum, and serum fractions of normal ras. Appreciable amounts of iron were found in at least one serum fraction other than that normlly reported--that is, transferrin iron, or the Fe-beta-1-globulin complex. This iron was evidenced both spectrophotometrically and radiometrically. The radiometric assessments were effected through 192 hours after injection with radioiron. Radioiron exists in measurable quantities in the cells, in the transferrin form, and in another serm subfraction throughout this interval. On the bsis of a purely empiric approach, and when the data are expressed as the specific activities of the iron in the various fractions of whole blood, certain kinetic-type functions would appear to exist. The apparent functions are replicable and, in more recent sudies, were successfully extrapolated with an unexpected amount of accuracy. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1961
- Accession Number
- AD0267828
Entities
People
- George S. Jr. Melville
- Robert W. Riess
- Thomas P. Leffingwell
Organizations
- United States Air Force School of Aerospace Medicine