THE RESPONSES OF ANIMALS INHALING NITROGEN DIOXIDE FOR SINGLE, SHORT-TERM EXPOSURES
Abstract
These experiments were designed to study the effects of NO(2) at various concentration levels below the LC50) (Lethal Concentration 50) for single, short-exposure periods to obtain concentration causing minimal effects to animals. Rats and rabbits were exposed to various concentrations of NO(2) for 5 to 60 minutes and the LC50's calculated. In addition, rats and dogs were exposed for single 5- to 60-minute periods to various concentrations of NO(2) below the rat LC50's. TOXIC SIGNS, PATHOLOGIC CHANGES IN THE LUNG AND LUNG-TO- BODY WEIGHT RATIOS CORRELATED DIRECTLY WITH THE SEVERITY OF EXPOSURE TO NO(2). Dogs showed only mild toxic signs at concentrations causing pulmonary edema in rats. Based on lung-to-body weight ratios and pathologic changes found, the concentrations of NO(2) at which minimal effects were found were 104, 65, and 28 ppm for 5, 15, and 60 minutes, respectively.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1961
- Accession Number
- AD0268216
Entities
People
- Frank T. Wilinski
- Mitchell J. Rosenholtz
- Theophilus R. Carson
Organizations
- Edgewood Chemical Biological Center