POTENTIATION BY PENTOBARBITAL OF THE PROTECTIVE EFFECT OF AET AGAINST GAMMA RAYS
Abstract
Female rats were treated with the radioprotective drug S,beta-aminoethylisothiuronium dibromide (AET) in combination with pentobarbital sodium and irradiated with various dosages of gamma rays. This treatment appears to depend less on dose rate of radiation than does AET given alone; it also reduces the amount of AET which must be used to achieve a given degree of protection. The combination is more effective than either compound given singly. The results of this study support further the hypothesis that chemical agents with different modes of action may be successfully combined to achieve better radioprotection. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1961
- Accession Number
- AD0268549
Entities
People
- George S. Jr. Melville
- Thomas P. Leffingwell
Organizations
- United States Air Force School of Aerospace Medicine