BIOLOGICAL AND IMMUNOLIGICAL STUDIES ON TOXOPLASMA
Abstract
A high virulent strain of Toxoplasma which usually does not produce cysts developed chronic infection in mice resulting in the production of cysts by the treatment of sulfa-drug. A low virulent strain which usually develops chronic infection and produces cysts became to have a high virulence by the serial transplantations of the proliferative forms appearing in the peritoneal cavity in the early part of the infection. Morphologically, cyst is produced by the accumulation in some substance on the inner surface of the limiting membrane of the vacuole in which the parasite is located. Along with the multiplication of the parasite by binary fission within the vacuole, the cystic membrane becomes much thicker and ultimately a homogeneous membrane encircling numerous parasites develops. High virulent strain does not produce cysts. This is probably due to the rapid prolefiration of the parasite: the vacuole containing the parasites will burst by the rapid expansion of the volume of the parasites before the definite cystic membrane is produced. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1961
- Accession Number
- AD0268605
Entities
People
- Hisakichi Matsubayashi
Organizations
- Keio University