EFFECT OF FLUID AND BLOOD ADMINISTRATION ON SURVIVAL OF THE ORGANISM SUBJECT TO VARIOUS TYPES OF HYPOVOLEMIC SHOCK
Abstract
Using refrigerator-stored tourniquet convalescent rat plasma collected under sterile conditions, there was a suggestion of improvement in early (24 hour) survival results after an otherwise lethal tourniquet trauma when compared with therapy using normal rat plasma. Forty-eight hour survival was not significantly different between groups. No difference in early or late survival is demonstrated after tourniquet trauma using slow frozen rat plasma, whether convalescent or normal, collected under non-sterile conditions. Freshly reconstituted human plasma is strikingly effective in the therapy of tourniquet trauma in the rat at a level of 3 milliliters plasma per 100 grams body weight. Human plasma, whether reconstituted or fresh, if then frozen loses this striking therapeutic effect at the same level of infusion. Fast frozen rat plasma (acetone and dry ice) is less efficacious than slowly frozen rat plasma. Both are less effective than freshly reconstituted human plasma. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 1961
- Accession Number
- AD0268642
Entities
People
- Morton D. Pareira