PREVENTION OF INITIAL HEMORRHAGE FROM SYNTHETIC VASCULAR PROSTHESES
Abstract
Segments of abdominal aorta in 25 dogs were replaced by knitted Dacron prostheses in studies concerned with limiting the blood loss which ordinarily occurs through the walls of porous prostheses when circulation is reestablished after the graft is inserted. Dacron prostheses which had been coated with Gelfoam permitted significant blood loss, as did prostheses which had been pre-clotted by immersion in blood from the host dogs. Grafts coated with Silastic, a silicone rubber, were nearly impervious to blood. Silicone reduced the initial interstitial blood loss dramatically, but the grafts were too stiff for easy anastomosis. The Silastic prevented penetration of the interstices of the graft by fibroblasts from the adventitial surface. The neo-intima was organized by fibroblasts which grew in from the ends of the graft. Despite the failure of host tissue to penetrate the interstices of the prostheses, all grafts remained patent. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1961
- Accession Number
- AD0268794
Entities
People
- Elmer V. Dahl
- John B. Fitzgerald
- William G. Malette
Organizations
- United States Air Force School of Aerospace Medicine