CHRONIC EFFECTS OF IONIZING RADIATION ON THE HEMATOPOIETIC SYSTEM
Abstract
Juvenile (weanling) female rats were exposed continuously to two different levels of radiation from a point source of 5.7 curies cobalt 60 (100 and 276 r/23 hour day). At the time of death of the animals, the total accumulated dose for the two levels was 4,000 roentgens, and, the survival times were 40 days and 15 days respectively. The growth curves for the different levels are compared. A decrease in growth as a function of dose rate was observed. Animals living in an environment of 23 r/day survived a total accumulated dose of over 12,000 roentgens. The results of a comprehensive microscopic and quantitative examination of the hematopoietic system at selected intervals during the course of exposure to ionizing radiation are recorded: peripheral blood, bond marrow, spleen, lymph gland and thymus. Erythrocyte size distribution in relation to progressive radiation exposure and associated with hemorrhagic manifestations is reported. The incidence, time of appearance and distribution of hemorrhagic complications is recorded from autopsy findings. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 10, 1961
- Accession Number
- AD0268846
Entities
People
- Charles E. Brambel
Organizations
- University of Notre Dame