THE SYNTHESIS OF POTENTIAL ANTI-RADIATION AGENTS
Abstract
Work concerned with the preparation of compounds in which the radioprotective 2-mercaptoethylamino grouping is attached to purines and pyrimidines, potentially capable of carrying it into nu leic acids, was completed. Since replacement of the sulfur of cysteamine with selenium does not destroy anti-radiation activity, the selenium analogs of a group of 2-aminoethylthiouronium salts, as well as their presumable physiological rearrangement products (2-aminoselenazolines and 2-selenoethylguanidines) were prepared. The bis Bunte salt of bis(2-mercaptoethyl)amine the doublearmed analog of cysteamine was synthesized. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 15, 1962
- Accession Number
- AD0269983
Entities
People
- Henry G. Mautner
Organizations
- Yale University