EFFECTS OF DRUG-INDUCED PERIPHERAL VASOCONSTRICTION AND VASODILATATION AND INCREASED HEAT PRODUCTION ON THE THERMAL AND METABOLIC RESPONSES OF DOGS EXPOSED TO COLD
Abstract
A study was designed to determine whether resistance to cold can be augmented by suitable pharmacologic adjustments of the heat loss and heat production mechanisms. Aramine-induced peripheral vasoconstriction in dogs was ineffective in preventing body cooling in the cold. Arfonad-induced cutaneous vasodilatation was also without benefit in the cold because it increased peripheral cooling due to a greater dermal heat flow and it reduced heat production as a result of an inhibitory side-effect on respiratory metabolism. Metabolic Stimulator (DNP) was beneficial in the cold in that the enhanced metabolism caused an initial pyrexia which slowed the fall in body temperature. The data indicated that pharmacologic modification of the insulation of the skin to adjust heat loss patterns was without benefit in inducing cold resistance, while drug-enhanced heat production and pyrexia appeared to have a possible favorable action on the tolerance of cold. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 14, 1961
- Accession Number
- AD0270146
Entities
People
- Clark M. Blatteis
Organizations
- United States Army Medical Research Laboratory