Variability of Different Intact Human-Skin Sites to the Penetration of VX

Abstract

Because it was suspected there might be a variability in the sensitivity to penetration of anatomically different skin area, doses of from 5 to 30 microgram/kg of VX were applied in a single drop to 19 intact skin sites on humans. Variations in penetration rates were determined from cholinesterase depression and incidence of symptoms. The following conclusions were reached: 1. Cholinesterase depression by sublethal doses of VX and incidence of symptoms are directly correlated. 2. There is a difference in sensitivity to penetration by VX of various body sites, the head and neck areas being the most sensitive. 3. The more rapid the penetration rate, the more rapid is the onset of toxic signs and symptoms. 4. Oximes appear to be effective in the treatment of VX intoxication.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1962
Accession Number
AD0271163

Entities

People

  • Van M. Sim

Organizations

  • Edgewood Chemical Biological Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Body Regions
  • Central Nervous System
  • Clinical Laboratories
  • Coefficients
  • Depression
  • Export Controls
  • Exports
  • Forehead
  • G Agents
  • Instructions
  • Measurement
  • Pain
  • Protective Equipment
  • Signs And Symptoms
  • Statistical Analysis

Fields of Study

  • Medicine

Readers

  • Geotechnical Engineering.
  • Toxicology/Environmental Toxicology