INCREASED CORTICOSTEROID BINDING (TRANSCORTIN) ACTIVITY IN ADRENALECTOMIZED AND HYPOPHYSECTOMIZED RATS

Abstract

Equilibrium dialysis experiments with pooled sera of rats demonstrate that the binding activity of the specific corticosteroid-binding protein (transcortin) is higher in adrenalectomized and hypophysectomized animals than in normal controls. Rat serum at both 4 C and 37 C has a higher binding affinity for corticosterone than for cortisol, whereas in human serum at 4 C, cortisol appears to be bound more fir ly than corticosterone. The transcortin systems of man and rat, therefore, show distinct differences. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jan 15, 1962
Accession Number
AD0272379

Entities

People

  • B.d. Ashley
  • U. Westphal
  • W.c. Williams

Organizations

  • United States Army Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Amino Acids Peptides And Proteins
  • Biomolecules
  • Biopolymers
  • Carrier Proteins
  • Chemical Compounds
  • Chemical Reaction Properties
  • Cortisol
  • Dialysis
  • Macromolecules
  • Proteins

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry