BASIC STUDIES IN PERCUTANEOUS ABSORPTION

Abstract

Alterations in the skin of rats maintained on a fat-free (EFA- deficient) diet were studied by biological, chemical and physical techniques. Skin from EFA-deficient rats showed parakeratosis, acanthosis and hypertrophy of the sebaceous glands. The water diffusion rate and electrical conductivity of skin rose sharply after six weeks of feeding the EFA-deficient diet. Also, EFA- deficient skin was more permeable to organic acids, amino acids, glucose and urea than normal skin. The permeability of skin from rats on diets deficient in vitamins A, B(6) and C was not altered. Skin permeability did not change in cases of magnesium deficiency or when low or high protein diets were fed to rats. Treatment with olive oil and with petroleum ether caused a small increase in the permeability of skin to both water and ions. Experiments indicate that n-butylamine penetrates normal rat skin readily. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1961
Accession Number
AD0272758

Entities

People

  • Bohdan R. Choman
  • Leonard J. Vinson
  • Marjorie D. Lehman
  • Thomas Masurat
  • Walter R. Koehler

Tags

DTIC Thesaurus Topics

  • Alkanes
  • Amines
  • Amino Acids
  • Chemical Analysis
  • Chemical Synthesis
  • Chemistry
  • Epidermis
  • Fatty Acids
  • Organic Chemistry

Fields of Study

  • Biology

Readers

  • Analytical Chemistry
  • Exercise and Sports Science.
  • Toxicology/Environmental Toxicology