EFFECT OF COLD STRESS ON LIPOGENESIS BY ADIPOSE TISSUE
Abstract
The effect of cold stress on acetate metabolism by adipose tissue was investigated. Cold stress did not affect the ability of the epididymal fat pad to oxidize acetate-1-C14 to C14O2. The addition of unlabeled glucose to the incubation medium did not influence the rate of acetate oxidation in the case of adipose tissue obtained from either control or cold-stressed rats. In the absence of unlabeled glucose, more fatty acids from acetate-1-C14 were synthesized by the adipose tissue from control rats than by that from cold-stressed rats, although very little was synthesized by either. The addition of unlabeled glucose to the incubation medium at the physiologic concentration of 100 mg/100 ml caused the adipose tissue from both normal and cold-stressed rats to form fatty acids at high rates. It is a striking finding that cold stress, which almost abolishes hepatic lipogenesis, does not appreciably alter adipose tissue lipogenesis. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1961
- Accession Number
- AD0275864
Entities
People
- E.j. Masoro
- Edith Porter
- Judith Patkin