STUDIES ON RADIATION-INDUCED CHIMERAS, EARLY DEVELOPMENT OF GRAFT-TO-HOST TOLERANCE; PREVENTION OF SECONDARY DISEASE BY ISOANTISERUM AND PREIRRADIATION OF MARROW DONOR
Abstract
The present experiments are concerned with the attempt to prevent or ameliorate the occurrence of secondary disease deaths in irradiated mice bearing foreign bone marrow grafts; in addition, certain aspects of graft-to-host tolerance in early radiation chimeras have been investigated. It is concluded that specific graft-to-host tolerance may develop relatively early in radiation chimeras, that it is possible to prevent or eliminate secondary disease in homologous radiation chimeras by suitable preirradiation of the marrow donors, and by injection into the chimeras of specific isoantiserum directed against the marrow donor. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 30, 1962
- Accession Number
- AD0276046
Entities
People
- L.j. Cole
- W.e. Davis
Organizations
- Naval Radiological Defense Laboratory