COLD INJURY AT THE CELLULAR LEVEL
Abstract
The effects of hypothermia on the tissues and cells were investigated. Hypothermia causes a significant increase in the metabolic rate of liver slices: it significantly depresses the metabolic rate of kidney cortex slices. There is strong evidence to suggest that the enzyme system responsible for moving pyruvate into the TCA cycle is potentiated. Increases in wet-dry ratios were seen in liver, kidney, and heart; however, they tended to be transitory. It is suggested that the ether-extractable lipid may be affected by hypothermia; this, however, was not statistically significant. Evidence of CNS damage was also noted; it may be a strain difference. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1961
- Accession Number
- AD0276834
Entities
People
- Robert W. Belknap
- S.f. Cook