EFFECTS OF 2-PAM AND EA 1814 ON NEUROMUSCULAR TRANSMISSION. I. EFFECTS OF 2-PAM AND EA 1814 ON THE FROG RECTUS ABDOMINIS MUSCLE PREPARATION
Abstract
Contracture of the isolated frog Rectus abdominis muscle was used to study pharmacological properties of 2-PAM (2-pyridine aldoxime methiodide) and EA 1814 (1, 1'-trimethylene bis(4-formyl pyridine bromide) dioxime), other than those relating to reactivation of inhibited cholinesterase (ChE). For example, concentrations of 2-PAM in excess of 4 x 10 to the -5th power M potentiate contractures of the frog rectus muscle elicited by acetylcholine (ACh). This potentiation appears to result from an anticholinesterase (antiChE) property of this oxime and not from a direct depolarizing action. 2-PAM inhibits the response to the depolarizing agents, decamethonium and carbamylcholine, which are not susceptible to hydrolysis by the ChE of frog rectus muscle, and to ACh, if the rectus muscle ChE is first inhibited with eserine. EA 1814 showed only inhibitory properties. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1962
- Accession Number
- AD0277693
Entities
People
- Joseph H. Fleisher
- Thomas H. Moen
Organizations
- Edgewood Chemical Biological Center