THE SYNTHESIS OF BETA-MERCAPTOETHYLAMINES OF VARYING BASICITY AND LIPOSOLUBILITY
Abstract
Derivatives of 2-mercaptoethylamine (MEA) and 2mercaptoethylguanidine (MEG) were synthesized to improve the toxicities and solubility characteristics of the parent compounds for radiation protection. This was accomplished mainly by alkylation with straight chain alkyl groups, and by acylation with straight chain aliphatic or alphaamino acids. Dithiocarbamates of these and other amines were also synthesized for antiradiation screening. The structure of the carbon disulfide adduct of MEG was investigated. Several other types of mercapto-containing compounds were synthesized as well: mercaptoethyl and dithiocarbamate derivatives of aminopyrimidines and amino-as-triazines, nitrogen derivatives of mercaptobiacetyl, and bithioureas. Metal chelation reactions of some of the dithiocarbamates were studied in an attempt to relate metal ion chelation with antiradiation activity. Stability constants were not obtained, but a relation between metal ion chelation and antifungal activity was observed. A majority of the compounds for which antiradiation results were reported during the past year gave protection in mice. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 25, 1962
- Accession Number
- AD0278003
Entities
People
- William O. Foye