Final Report, 1 November 1958-31 October 1961,
Abstract
The absolute configuration of yohimbine: Chemical approaches to the solution of yohimbine structures by degradation to products of known stereochemistry are discussed. The absolute configuration of strychnine: Attempts to convert strychnine to dihydrocorynantheane are reported. Gelsedine: The alkaloid gelsedine was shown to be demethoxygelsemicine. A chemical and spectral study of oxindole model compounds is discussed. A flavopereirine synthesis: The reactions of several N-(beta-(3-indolyl-)ethyl-)pyridinium salts with various metal hydrides were investigated. Their use in the synthesis of the alkaloid flavopereirine is reported. A synthesis of erythrocentaurin: The chemistry of hemimellitic acid was investigated. The homologation and reduction of some carboxyphthalides and pyrolysis and reduction of others was studied. Acylation of dimethyl 2-methylisophthalate and its dinitrile was investigated; the chemistry of the resulting isocoumarin and isocarbostyril is discussed. The conversion of the isocoumarin derivative into erythrocentaurin is described.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 31, 1961
- Accession Number
- AD0278106
Entities
People
- Ernest Wenkert
Organizations
- Iowa State University