SYNTHESIS OF ANTIRADIATION DRUGS
Abstract
Forty-eight compounds were synthesized and evaluated as potential antiradiation drugs. These compounds were mainly N-substituted derivatives of 2-aminoethanethiol and were supplied as the hydrochloride salts. The synthetic methods used were: (1) thiolethylation of amines and alkanolamines with ethylene sulfide; (2) amination of epoxides and alpha, omega-alkylene dihalides with 2-(Benzylthio)ethylamine, followed by debenzylation; and (3) alkylation of alkanolamines with benzyl 2-chloroethyl sulfide, followed by debenzylation. A study of the reaction variables in the ethylene sulfide thiolethylation of a simple aliphatic amine (n-hexylamine) was begun. The data indicate that high amine:episulfide molar ratios and long reflux periods favor formation of the monothiolethylated product in good yield. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 20, 1962
- Accession Number
- AD0278124
Entities
People
- Morton H. Gollis
- Robert J. Wineman
Organizations
- Monsanto