DETERMINATION OF THE CRITICAL AMBIENT TEMPERATURE FOR MICE TREATED WITH CHLORPROMAZINE

Abstract

Chlorpromazine can have a hypothermic or hyperthermic effect on the body temperature response of mice, depending upon the ambient temperature. The critical ambient temperature has been calculated to be approximately 33 C using two milligrams per kilogram of chlorpromazine in mice. The ambient temperature is an important factor that can bias the effect of drugs that influence body temperature and should be weighed accordingly when data are analyzed. The influence of other factors such as radiation, relative humidity and air motion has been discussed. ( uthor)

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1961
Accession Number
AD0278529

Entities

People

  • Fred Miya
  • Stanley Marcus

Tags

DTIC Thesaurus Topics

  • Body Temperature
  • Chlorpromazine
  • Humidity
  • Radiation
  • Wet Bulb Temperature

Readers

  • Thermal Physics or Thermal Science.
  • Toxicology/Environmental Toxicology