EFFECT OF AMBIENT TEMPERATURE AND CHLORPROMAZINE TREATMENT ON RESISTANCE OF MICE CHALLENGED WITH KLEBSIELLA PNEUMONIAE

Abstract

The hypothesis that increased metabolic rates enhance the host resistance to infection was investigated. Chlorpromazine was used to induce the state of hypothermic stress without compensatory increase in metabolic rates. The results of the experiments showed that the ambient environment influences the toxicity of the drug itself. Chlorpromazie enhanced the death of mice challenged with Klebsiella pneumoniae, and an interpretation could be that the lowering of metabolic rates as a result of the drug injection was contributory to this effect.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1961
Accession Number
AD0278530

Entities

People

  • Fred Miya
  • Lagrand J. Phelps
  • Laval Spencer
  • Stanley Marcus

Organizations

  • University of Utah

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Central Nervous System
  • Chlorpromazine
  • Climate Change
  • Continents
  • Geographic Regions
  • Government Procurement
  • Governments
  • High Temperature
  • Hypothermia
  • Materials
  • Nervous System
  • New York
  • North America
  • Resistance
  • Standards
  • Universities

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Immunology
  • Thermal Physics or Thermal Science.