STEROID-PROTEIN INTERACTIONS. IX. THE INTERACTION OF ALDOSTERONE WITH HUMAN SERUM PROTEINS IN COMPETITION WITH SPIROLACTONES AND OTHER STEROIDS
Abstract
The physiological action of aldosterone is antagonized by spirolactones. In view of the possibility that this effect is mediated through a competition for a protein receptor, the interaction of readily available serum proteins with aldosterone and other steroids was investigated. In relatively large concentrations the spirolactones displaced aldosterone from human serum proteins; however, greater displacement of aldosterone was obtained when cortisol or progesterone was used. Aldosterone was found to interact more strongly with whole serum than with albumin, at both 37 and 4 C. These studies provide an insight into the influence of spirolactones on aldosterone-protein interaction. Similar studies at the renal tubular level are necessary to clarify the significance of this interaction. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 14, 1962
- Accession Number
- AD0283278
Entities
People
- E.t. Davidson
- F. Devenuto
- U. Westphal
Organizations
- United States Army Medical Research Laboratory