RESEARCH ON EFFECTS OF ACETYLCHOLINE ON THE MAMMALIAN MOTOR END-PLATE

Abstract

Investigations of the electrophysiological properties of the mammalian motor end-plate reveal: (1) Prolonged or intermittent application of acetylcholine desensitizes the chemoreceptors of the motor end-plate. (2) The motor nerve controls the size of the chemosensitive surface in muscle fiber, presumably through the release of a chemical mediator. (3) The chemical sensitivity of end-plate receptors in muscles from patients with myasthenia gravis is normal, suggesting that the neuromuscular defect in this disease is of pre-junctional origin.

Document Details

Document Type
Technical Report
Publication Date
Aug 25, 1962
Accession Number
AD0284909

Entities

People

  • Stephen Thesleff

Organizations

  • Lund University

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Chemoreceptors
  • End Organs
  • Muscle Fibers
  • Muscles
  • Musculoskeletal System
  • Sensitivity

Fields of Study

  • Medicine

Readers

  • Aerosol Science/Aerosol Physics
  • Neuroscience
  • Neurotoxicology