THE PROPERDIN SYSTEM IN HOST RESISTANCE
Abstract
Evidence is reviewed through 1960 that supports the existence in mammalian sera of the serum protein fraction named properdin. Characteristics of the controversy concerning the distinctions between antibody and properdin are reviewed. Methods of isolation and assay, as well as problems related to assay, are considered and evalu-ATED. The interactions of properdin are described with various substances, such as polysaccharides, divalent cations, complement, and complement fractions. The reported effects of properdin on different types of bacteria, viruses, and neoplasms, in culture or in animals, are evaluated in conjunction with other nonspecific defense mechanisms which have been described. Absence of information of the mechanism of action of properdin in host resistance indicates need for investigation in this area. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1962
- Accession Number
- AD0285016
Entities
People
- Fred Miya
- Stanley Marcus
- William Wu
Organizations
- University of Utah