Immunological Studies with Bacillus Anthracis. Bacillus Anthracis Aerosol Challenge of Guinea Pigs Vaccinated with Protective Antigen.

Abstract

This study indicated that three separate injections of Bacillus anthracis protective antigen provided a higher level of immunity than one injection when guinea pigs were challenged by the respiratory route with two different strains (V1B and NH6) of Bacillus anthracis. Based on LD5O values obtained with control animals, protective antigen provided a higher level of resistance against intracutaneous route of challenge than the respiratory. Immunized animals challenged intracutaneously with strain NH6 displayed a much lower level of resistance against this route than that observed for strain VlB. Averaged LD5O values obtained with control guinea pigs indicated that strain VlB was more virulent via the respiratory route than strain NH6.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1962
Accession Number
AD0285614

Entities

People

  • Gerald H. Tepaske
  • Henry C. Wallace
  • Ruth R. Bailey
  • William C. Day

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Animals
  • Antibodies
  • Biomedical Research
  • Confidence Limits
  • Government Procurement
  • Hydroxides
  • Immunity
  • Immunization
  • Materials
  • Medical Personnel
  • Precipitation
  • Resistance
  • Rhesus Monkeys
  • Rodents
  • Statistical Analysis
  • Technical Information Centers
  • Vaccination

Fields of Study

  • Biology

Readers

  • Immunology

Technology Areas

  • Biotechnology