BIOCHEMICAL MECHANISMS RELATED TO THE HOMEOSTATIC REGULATION OF LIPOGENESIS IN ANIMALS
Abstract
The physiologic regulation of lipogenesis is discussed. The site of regulation in th enzy ic sequenc of fatty acid synt i appears to be the acetyl CoA carboxylase step. The following h ve been excluded as having importance in this regulation: (a) intracellular acetyl CoA levels; (b) the rate of TPNH generation; (c) direct actio s of hor ones. The follo ing mecha isms appear to play rol i h co trol of lipogenesis: (a) co c r tio of ac tyl CoA carboxylase; (b) lipogenic inhibitors; (c) lipog nic timulators; (d) the level of tricarboxylic acid intermediates; ( E) the concentration of CoA; (f) the level of FFA. Instead of considering t e ec ni m co trolling lipogenesis, i ms or lik ly t at this problem can only be unders ood by co i ring t multiple nature of the specific chemical events controlling fatty acid synth si . ( uthor
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1962
- Accession Number
- AD0286514
Entities
People
- E.j. Masoro
Organizations
- Tufts University