EVIDENCE THAT RHESUS MONKEYS DIE FROM ANTHRAX TOXIN
Abstract
Evidence that a toxin produced by B. anthracis causes death in animals has been extant since as early as 1931. Recognition of these evidence and their reverification have been left until this decade, when Smith et al. (1955) and later workers demonstrated that the terminal shock from toxin is the major cause of death in anthrax. In this paper evidence is presented that: (1) Anthrax toxin can be demonstrated in body fluids of the Rhesus monkey at death. (2) Anthrax toxin is present in increasing amounts in body fluids of Rhesus monkey dying of anthrax. (3) In vitro produced, sterile anthrax toxin is capable of causing the death of Rhesus monkey. (4) Anthrax antiserum protects the Rhesus monkey against in vitro toxin produced by B. anthracis. These findings imply that the treatment of the disease in man should be revised to include use of antitoxin for neutralization effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1962
- Accession Number
- AD0286636
Entities
People
- B. G. Mahlandt
- B. W. Haines
- D. R. Hodges
- F. Klein
- W. I. Jones
Organizations
- United States Army Biological Warfare Laboratories