LESIONS IN THE ORAL TISSUES INDUCED BY EXPOSURE TO MULTIPLE SUBLETHAL DOSES OF TOTAL BODY X-IRRADIATION IN THE MOUSE AND THE EFFECTS OF DIETARY SUPPLEMENTS OF BIOFLAVONOIDS THEREON
Abstract
The effects of multiple sublethal doses of total body x-irradiation were determined on the oral tissues of mice fed a highly purified basal ration and the basal ration plus supplements of bioflavonoids of diverse structure and physicochemical properties. Similar lesions were observed in all x-irradiated mice with no significant differences between the various dietary groups. The lesions observed include rarefaction, collagenolysis, pyknosis, canalization with capillaries, and inclusions of squamous epithelium and osteoclasts of the periodontium; focal resorption of the acellular cementum; osteoclastic inclusions in the dentin; acute gingivitis and interdental pyorrhea; decreased trabiculation and bone marrow of the alveolar bone; and neoplastic changes of the lacrimal gland, submaxillary salivary gland and squamous epithelium. Lesions comparable to the above were not observed in non-irradiated mice in the various dietary groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 31, 1962
- Accession Number
- AD0286799
Entities
People
- Benjamin H. Ershoff