PHARMACOLOGICAL STUDY ON CENTRAL SYNAPTIC SYSTEMS AFFECTING MOTOR FUNCTION
Abstract
A series of compounds with known activity in regard to their actions on synaptic reflexes and the central nervous system were investigated. Agents that are skeletal muscle relaxants act by depressing or interrupting transmission of nerve impulses through polysynaptic pathways. Included in this group of compounds are zoxazolamine and mephenesin. These agents also act on brain stem and subcortical areas. They have no direct effect on myoneural junction and, in lower concentration, no effect on monosynaptic pathways. The muscle relaxant properties of a number of compou ds were studied. In addition to their effects on neuro-muscular activity, these substances also have pronounced effects on the central nervous system, as evidenced by increased respiratory rate changes in temperament, and pubil size. In continuing these studies, we have confin d our attention to the CNS effects of one particular substance, Compound No. 6. Attempt were made to screen po sible antago ist . The possible antagonistic actions of tetrahydroamino acridine (THA) and physostigmine sulfate were studied in detail. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1962
- Accession Number
- AD0286956
Entities
People
- Samuel D. Anderson
- William C. Holland
Organizations
- University of Mississippi