TOLERANCE CRITERIA FOR CONTINUOUS INHALATION EXPOSURE TO TOXIC MATERIAL. II. EFFECTS ON ANIMALS OF 90-DAY EXPOSURE TO H2S, METHYL MERCAPTAN, INDOLE, AND A MIXTURE OF H2S, METHYL MERCAPTAN, INDOLE, AND SKATOLE

Abstract

Closed-cycle ecological systems, Primates, Laboratory animals, Methyl radicals, Metabolic products. Identifiers: Urinalysis, Liver function tests, Heinz bodies. Physiological changes in rats, mice, and monkeys were studied during continuous 90-day exposure to controlled atmospheres of toxic vapors and gases which might be expected to accumulate within a space capsule. Concentrations of test chemicals were those recognized as Industrial Threshold Limit Values and included: (a) hydrogen sulfide (20 ppm), (b) methyl mercaptan (50 ppm), (c) indole (10.5 ppm), and (d) a mixture of these three compounds plus skatole (3.5 ppm). Mortality rates were high only in the group exposed to a mixture of four compounds. There was evidence that animals can adapt to tolerate otherwise lethal concentrations.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1961
Accession Number
AD0287797

Entities

People

  • Curtis Sandage

Organizations

  • MRIGlobal

Tags

DTIC Thesaurus Topics

  • Air Force
  • Brain
  • Chemical Analysis
  • Chemical Synthesis
  • Chemical Warfare Agents
  • Chemistry
  • Clinical Laboratories
  • Hydrogen
  • Hydroxides
  • Indicator Dyes
  • Materials
  • Medical Laboratories
  • Medical Personnel
  • Statistical Analysis
  • Stress Tests
  • Two Dimensional
  • United States

Fields of Study

  • Environmental science

Readers

  • Analytical Chemistry
  • Toxicology/Environmental Toxicology

Technology Areas

  • Space
  • Space - Orbital Debris