EXPERIMENTAL PRIMARY CUTANEOUS COCCIDIOIDOMYCOSIS IN THE MONKEY
Abstract
Primary cutaneous coccidioidomycosis was studied in the monkeys (Macaca mulatta) to find a suitable strain of Coccidioides immitis for use as a viable vaccine. Intradermal inoculation (medial surface of the right forearm) produced more severe vaccination reactions (draining vaccination site and axillary lymph node hypertrophy) than subcutaneous injection. A subcutaneous vaccine dose of ten arthrospores resulted in less reaction than a 100-spore dose. Moreover, dissemination beyond the regional lymph nodes did not occur, following injection of ten spores of even the most virulent strains of C. immitis. Two of the five strains tested (Silveira, M-11, D-76, Cash, and a colonial isolate from Cash designated as CW1) exhibited very mild vaccination reactions and appeared to have been cleared from the tissues upon necropsy at 10 months post-challenge. These two strains (Cash and CW1) appear promising for further immunological studies with a viable vaccine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1962
- Accession Number
- AD0288870
Entities
People
- Ernest M. Snyder
- John L. Converse
- Merida W. Castleberry
- Steven P. Pakes
Organizations
- United States Army Biological Warfare Laboratories