DETERMINATION OF 1,1-DIMETHYLHYDRAZINE (UDMH) IN URINE

Abstract

The colorimetric determination of 1,1-dimethylhydrazine (UDMH) in urine using trisodium pentacyanoamino ferroate (TPF) has heretofore been hampered by interfering substances in urine which resulted in poor recovery and some false negative results. A procedure was developed which overcame this difficulty and was primarily designed to determine rapidly in an emergency situation the urinary concentration of UDMH in exposed personnel. The procedure involves a hydrogen peroxide treatment of the urine followed by a colorimetric complexing of UDMH with TPF. In vivo results are presented on dogs that received intraperitoneal doses of UDMH with urinary concentrations of UDMH being determined in spontaneously voided and 24-hour pooled specimens. The results give some indication of the relationship of dose to excretion levels. In vitro recovery in 100 human urine specimens is presented.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1962
Accession Number
AD0288876

Entities

People

  • Anthony A. Thomas
  • Philip Diamond

Organizations

  • Air Force Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Biomedical Research
  • Blood
  • Chemistry
  • Dimethylhydrazines
  • Hydrazine Derivatives
  • Hydrazines
  • Hydroxides
  • Materials
  • Medical Personnel
  • Physiology
  • Rocket Oxidizers
  • Standardization
  • Standards
  • Time-Domain Reflectometry
  • Toxic Hazards

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Cardiovascular Physiology
  • Rocket Propulsion.
  • Virology (or Medical Virology).