THE DUAL NATURE OF RESISTANCE MECHANISMS AS REVEALED BY STUDIES OF ANTHRAX SEPTICEMIA

Abstract

From studies of septicemic anthrax, resistance is described in relation to toxin and to growth of bacilli. this description is based on the observations that the terminal concentrations of bacilli in the blood are influenced primarily by the susceptibility of the host to toxin, whereas the death response time of the host is dependent on both resistance to bacilli and toxin susceptibility. resistance to the establishment and growth of infecting organisms and susceptibility to the toxin produced by growth of the bacilli are separate aspects of pathogenesis. a complete description of pathogenesis must treat accordingly both these phenomena as individual entities.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1962
Accession Number
AD0289683

Entities

People

  • Bertram W. Haines
  • Bill G. Mahlandt
  • Frederick Klein
  • Ira A. Dearmon Jr.
  • Ralph E. Lincoln

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Biological Laboratories
  • Cells
  • Confidence Limits
  • Diseases And Disorders
  • Health Services
  • Infection
  • Intervals
  • Laboratory Animals
  • New York
  • Observation
  • Pathogenesis
  • Resistance
  • Rodents
  • Septicemia
  • United States
  • Wound Infections

Readers

  • Immunology
  • Theoretical Analysis.