EFFECT OF CORTISONE ON THE COURSE OF THE INFECTIOUS PROCESS IN WHITE MICE INFECTED WITH PATHOGENIC MICROORGANISMS
Abstract
Under experimental conditions cortisone considerably increased the sensitivity of white mice to pseudotuberculosis, listerellosis, pasteurellosis, erysipeloid, and salmonellosis; therefore, cortisone-treated white mice can be employed as a very sensitive biotest in carrying out corresponding analyses. Cortisone markedly increased the sensitivity of white mice to the vaccine culture of plague and tularemia microorganisms and thus, can be utilized in individual experimental investigations. In experiments with highly virulent tularemia and plague cultures, to which white mice are highly sensitive even without cortisone, no further increase has been observed in the sensitivity of animals to infection (tularemia), or their sensitivity increased only slightly (plague). Upon examination of wild rodents in the natural plague nidi, no advantages could be elicited from the use of cortisone-treated white mice for biological tests.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1962
- Accession Number
- AD0291638
Entities
People
- G. V. Yushchenko
- M. P. Tereshchenko
- N. S. Ognena
- R. V. Kovaleva
- T. N. Ponomareva
Organizations
- United States Army Biological Warfare Laboratories