STEROID-PROTEIN INTERACTIONS
Abstract
Studies on Sprague-Dawle rats have shown that the high-affinity corticosteroid-binding activity of serum increases after adrenalectomy or hypophysectromy. This increa e becomes apparent etween the first and sec nd day after adrenalectomy, goes up to approximately twice the normal binding activity and remains at this level for at least 3 weeks. Injection of large doses of corticosterone into the adrenalectomized rat decreases the corticosteroid-binding activity to the same low level as observed in n rmal rat after injection of the same dose of corticosterone. A species-specificity was demonstrated: the binding protein in rat ser m was found to bind corticosterone more firmly than cortisol, whereas the opposite relationship was observe for human transcortin. Electrophoretic studies showed the corticosteroid-binding protein in rat serum to be an alpha globulin. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 15, 1962
- Accession Number
- AD0291853
Entities
People
- Ulrich F. Westphal
Organizations
- University of Louisville