PHARMACOLOGY AND TOXICOLOGY OF 1,1-DIMETHYL-HYDRAZINE (UDMH)
Abstract
The acute LD50 of UDMH in mice, rats, dogs, and monkeys by intraperitoneal administration was found to be 125 mg/kg, 104 mg/kg, 60-100 mg/ kg, and 60-100 mg/kg, respectively. All animals exhibited clonic-tonic convulsions as the predominant symptom, and death was via respiratory arrest. Dogs and monkeys routinely showed emesis within 15-60 minutes following dose of UDMH, regardless of route. In the anesthetized dog UDMH did not alter the effects of epinephrine, norepinephrine, acetylcholine, histamine, or reserpine on blood pressure. It did not significantly affect autonomic ganglia or postganglionic nerve endings, nor did it markedly alter the electrocardiogram or blood pressure in 1-2 hours. In the unanesthetized dog, however, blood pressure was significantly increased until convulsions and respiratory arrest occurred.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1962
- Accession Number
- AD0292689
Entities
People
- Anthony A. Thomas
- Kenneth C. Back
Organizations
- Air Force Research Laboratory