THE METABOLISM OF SIMPLE COMPOUNDS IN MICRO-ORGANISMS
Abstract
Results obtained indicate that: (1) the formation of isocitrate lyase when E. coli grow on acetate is a consequence of de novo protein synthesis; (2) acetate per se is not an inducer of isocitrate lyase formation but acts in an indirect manner, probably by relieving enzyme repression; (3) growth of Rps. spheroides on acetate, aerobically in the dark or anaerobically in the light, does not involve the glyoxylate cycle; (4) anaerobic growth of an organism, tentatively identified as Cl. kluyveri, on ethanol plus acetate also does not involve the glyoxylate cycle; (5) inducible amidase formation by Ps. aeruginosa growing on acetamide is discontinuous and either the nature of the enzyme formed or its mode of formation is influenced by the nature of the inducing agent; (6) growth of M. denitrificans on glycollate involves a new route in which betahydroxyaspartate may be an intermediate; and (7) growth of Pseudomonas sp. on itaconate necessitates its prior activation to itaconyl coenzyme A, which is transformed to pyruvate and acetyl coenzyme A, probably via citramalyl coenzyme A. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 20, 1962
- Accession Number
- AD0292926
Entities
People
- H.l. Kornberg
Organizations
- University of Leicester