Mixed Infections of Venezuelan Equine Encephalomyelitis and Q Fever in Macaca Mulatta Monkeys

Abstract

Studies suggest that the Macaca mulatto monkey, when exposed simultaneously to aerosols of the Trinidad strain of Venezuelan equine encephalomyelitis virus (500 to 700 respiratory infectious doses) and the AD strain of Coxiella burnetii (10 to 30 respiratory infectious doses), exhibits a concurrent mixed infection with VEE and Q fever. The course of the dual infection in the monkey is characterized by an abrupt early onset of viremia and febrile response (48 to 72 hours) to VEE that lasts approximately eight days. The onset of Q fever, as characterized by a rickettsemia, occurs in the final stages of VEE infection (seventh to eleventh days); recovery of rickettsiae from monkey blood persists beyond the fifteenth day after aerosol exposure. The presence of VEE virus-neutralizing antibody and Q fever complement-fixing antibody in 28-day convalescent serum supports these findings.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1962
Accession Number
AD0293694

Entities

People

  • Nicholas L. Pollok Iii

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Arbovirus Infections
  • Biomedical Research
  • Blood
  • Cells
  • Coinfection
  • Diseases And Disorders
  • Infection
  • Materials
  • Q Fever
  • Rodents
  • Serodiagnosis
  • Trinidad
  • Venezuelan Equine Encephalomyelitis
  • Virus Diseases
  • Viruses
  • Yellow Fever

Fields of Study

  • Biology

Readers

  • Immunology
  • Mathematics or Statistics
  • Virology (or Medical Virology).