EFFECT OF LOW AMBIENT TEMPERATURES ON SPECIFIC AND NONSPECIFIC RESISTANCE OF MICE TO BACTERIAL DISEASE
Abstract
Experiments were designed to compare specific and nonspecific resistance to induced bacterial disease in mice placed at 2 C. The animals were acclimatized or unacclimatized to the low temperature. It was found that specific resistanceAFFORDED THE MAXIMAL PROTECTION POSSIBLE WHEREAS NONSPECIFIC RESISTANCE WAS OF RELATIVELY LOW EXTENT. The low ambient temperature did not interfere with protection gained from specific immunization provided the cold-exposed mice were caged in small groups (10 per group) as compared to individually caged animals. The difference in results between isolated and grouped animals was not due to conservation of heat by huddling. It appears that the effect of isolation contributes to enhanced mortality following challenge. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1962
- Accession Number
- AD0294815
Entities
People
- F. Miya
- S. Marcus
Organizations
- University of Utah