PYRIDINE NUCLEOTIDE OXIDASES AND TRANSHYDROGENASE IN ACCLIMATIZATION TO HIGH ALTITUDE
Abstract
Activity of pyridine nucleotide oxidases and transhydrogenase has been examined in heart, liver, and rectus femoris muscle of guinea pigs native of sea level and high altitude. There was an enhanced, reduced form of diphosphopyridine nucleotide oxidase (DPNH-oxidase) and transhydrogenase activity in heart and muscle from animals adapted to high altitude. The higher activity in muscle at altitude was due solely to increase in ratio of red to white portions. Both groups showed the pigmented portion twice as active as the white one. In liver, neither the DPNH-oxidase system nor the transhydrogenase was significantly changed in their activity on a fresh-weight basis. Nevertheless, the DPNH-oxidase is higher at altitude when the activity is expressed per gram of nitrogen. The reduced form of triphosphopyridine nucleotide oxidase activity was not appreciably changed in any of the tissues. It was concluded that adaptation to high altitude is associated with apparent changes in the magnitude of the electron transport pathway. Increased activity in skeletal muscle is probably related to the tissue pigment content.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1962
- Accession Number
- AD0296334
Entities
People
- Baltazar Reynafarje