ION EFFECTS IN X-RAY DEPOLARIZATION OF MUSCLE MEMBRANE

Abstract

Irradiation of frog satorius muscles with 100 Kr of X-rays results in a relative decrease in resting membrane potential which is dependent on external sodium concentration, but not on potassium concentration provided that the latter exceeds 1.0 mM. In zero potassium solutions, the potential decreases more, and continues to fall after irradiation. Neither irradiation nor stimulation alters the rate at which Ca45 is lost from previously loaded muscle fibers. Apparently irradiation damage to the muscle cell membrane results in increased permeability to sodium, but not via the release of calcium ions. Sodium extrusion mechanisms are altered by irradiation so as to require an external potassium concentration above 1.0mm to match the increase of Na influx. Permeability to potassium does not appear to be altered by irradiation.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1962
Accession Number
AD0296447

Entities

People

  • Adolfo Portela
  • Juan C. Perez

Organizations

  • Emory University

Tags

DTIC Thesaurus Topics

  • Cell Membrane
  • Cells
  • Depolarization
  • Electrical Measurement
  • Extrusion
  • Government Procurement
  • Measurement
  • Membrane Potentials
  • Membranes
  • Muscle Cells
  • Muscle Fibers
  • Muscles
  • Permeability
  • Potassium
  • Radiation Effects
  • Standards
  • X Rays

Readers

  • Cardiovascular Physiology
  • Nuclear and Radiation Engineering.