HETEROGENEITY OF CANCER CELL POPULATION WITH REGARD TO THE NATURAL DRUG RESISTANCE OF CANCER CELL
Abstract
The actual state of drug resistance of tumor cell population is a matter of ''grading'' when it is considered on the cellular level. Every tumor has its own peculiar grade of ''natural'' drug resistance and the grade is not a fixed value but it can fluctuate naturally around a certain level within a limited range of variations corresponding to the resistance of its cell population. Population analysis of a neoplastic population, after establishing single cell clones from the population, has so far demonstrated that the tumor cell population is not of a homogeneous constitution but is a heterogeneous complex of cells of fluctuated grades of drug resistance. The resistance of a tumor cell population, therefore, is the averaged sum of all that of its constituents which differ from each other in their grade of resistance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 1963
- Accession Number
- AD0296480
Entities
People
- Tomizo Yoshida