PROTECTION AGAINST IONIZING RADIATION: X-IRRADIATED MONKEYS RECEIVING PREIRRADIATION PROPHYLAXIS AND POSTIRRADIATION THERAPY
Abstract
In this study, post irradiation symptomatic therapy of the radiation syndrome has been utilized to provide significant extension of survival time, compared to irradiated controls, of monkeys x-irradiated to a total dose of 900 r. Further, the therapeutic regimen has been successfully combined with chemical radioprotectants to enhance survival time in a third group of animals. This combined treatment is more effective than the therapy alone. The overall clinical condition of these animals is far superior to that of the untreated irradiated animals. Pathologic studies of the deceased animals indicate that the two major causes of death were bone marrow failure and severe lymphoid atrophy. The protective chemical treatment is in itself a combination of different mechanisms of radioprotection, routes of administration, and sites and rates of absorption of the drugs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1962
- Accession Number
- AD0296556
Entities
People
- George S.
- George W. Harrison
Organizations
- United States Air Force School of Aerospace Medicine