IMMUNIZATION AGAINST PLAGUE BY A SPECIFIC FRACTION OF PASTEURELLA PSEUDOTURBERCULOSIS

Abstract

An antigen, designated PP, common to Pasteurella pestis and Pasteurella pseudotuberculosis, has been isolated free of antigens detectable by gel diffusion. It will protect guinea pigs against plague one day after vaccination. PP apparently is a protein lipopolyssccharide complex and is analogous to endotoxin in incroasing resistance to infection, but is nontoxic in mice and guinea pigs. PP is different from and does not contain any of the antigens that have been shown previously to protact against plague.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1963
Accession Number
AD0299869

Entities

People

  • M. J. Surgalla
  • W. D. Lawton

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Bacteria
  • Bacterial Infections
  • Carbohydrates
  • Cells
  • Endotoxins
  • Gammaproteobacteria
  • Gram-Negative Bacterial Infections
  • Immunity
  • Infection
  • Laboratory Animals
  • Materials
  • Proteins
  • Rodents
  • Vaccination
  • Vaccines
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology

Technology Areas

  • Biotechnology