IONIZING RADIATION INJURY, PREVENTION AND TREAT MENT (CHEMICAL PROTECTION AGAINST TOTAL BODY RADIATION)
Abstract
The Antiradiation Drug Development Program con tinues to make progress in the development of events useful for prrotecting animals against ion izing injury. Agents have been found which have an increased therapeutic index; for the first time since the inception of the program a com pound has been found which exhibits some protec tive activity at 1/8th of the maximum tolerated level. Continued success is to be found in another series of antiradiation agents which are effective in very small amounts. These compounds which formerly were not effective by mouth have now been modified so that they may be given orally. Histamine release which was an important toxic side effect has been greatly reduced. The continued success in drug development convinces us that an antiradiation pill offering a dose reduction of approximately two to one can be developed for man and will not possess appre ciable side effects. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1963
- Accession Number
- AD0345806
Entities
People
- David P. Jacobus
- Joshua E. Henderson
- Thomas R. Sweeney
Organizations
- Walter Reed Army Institute of Research