THE HUMAN ASSESSMENT OF EA 1729 AND EA 3528 BY THE INHALATION ROUTE
Abstract
A study of the inhalation effectiveness of agent EA 1729 (d-lysergic acid diethylamide) and its maleate salt was conducted in which retained doses ranging from 0.3 to 7.8 micron g/kg were administered to 60 military volunteers. Onset time for the effective aerosol dose is about 15 min, peak time about 1-1/2 hr, and partial recovery time about 5-1/2 hr. Full recovery requires at least 12 hr. The safety factor in man cannot be stated with certainty. If man resembles most other animals in his toxicological response, the ratio of lethal to effective dose would be very high; however, there is not direct information about lethality in man. By the aerosol dissemination technique employed the effectiveness of the aerosol route is 0.25 to 0.30 that of the oral or intravenous routes. Prior exposure to the agent does not significantly influence the numerical facility performance decrement observed when an equivalent dose is given 2 weeks later.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1964
- Accession Number
- AD0351962
Entities
People
- George K. Aghajanian
- James S. Ketchum
- Oscar H. L. Bing
Organizations
- Edgewood Chemical Biological Center